CM 001
Chromafenozide
CAS: 143807-66-3
Molecular Formula: C24H30N2O3
CM 001 - Names and Identifiers
| Name | Chromafenozide |
| Synonyms | Killat CM 001 ans-118 carbochrozide Chromafenozide CHROMAFENOZIDE CHROMAFENOZIDE STANDARD chromafenozide (bsi, pa iso) 2'-tert-butyl-5-methyl-2'-(3,5-xyloyl) chromane-6-carbohydrazide |
| CAS | 143807-66-3 |
| EINECS | 200-154-8 |
CM 001 - Physico-chemical Properties
| Molecular Formula | C24H30N2O3 |
| Molar Mass | 394.51 |
| Density | 1.173g/cm3 (20℃) |
| Melting Point | 186.4° |
| pKa | 10.91±0.20(Predicted) |
| Storage Condition | 0-6°C |
| Physical and Chemical Properties | The pure product is white crystal with melting point of 186.4 ℃, vapor pressure of 4 × 10-9Pa(25 ℃) and solubility of 1.12mg/L (20 ℃) in water. |
CM 001 - Risk and Safety
| Risk Codes | 53 - May cause long-term adverse effects in the aquatic environment |
| Toxicity | LD50 (mg/kg) orally in rats, mice: >5000; dermally in rabbits: >2000; LC50 (mg/l) in rats: >4.68 by inhalation; in carp, rainbow trout (96 hr): >47.25, >18.9 (Yanagi) |
CM 001 - Reference Information
| use | 2 '-tert-butyl -5-methyl -2'-(3, 5-dimethylbenzoyl) color full -6-methylhydrazine can be used as an intermediate in pharmaceutical synthesis. dihydrazide insect growth regulators have excellent insecticidal activity against lepidopteran larvae. Insect ingestion inhibits insect feeding within a few hours, and at the same time causes early molting and death. The agent interferes with the ecdysis process of insects by regulating the activity of larval hormones and ecdysis hormones. It can be used for vegetables, field crops, fruit trees and ornamental plants, and the recommended dosage is 50~100mg/km2. |
| Preparation | 2 '-tert-butyl -5-methyl -2'-(3, 5-dimethylbenzoyl) color full-6-methylhydrazine can be made of 5-methylbenzodihydropyran -6-carboxylic acid as the reaction raw material, the intermediate N-5-methylbenzodihydropyran-6-carbonyl-N′-tert-butyl hydrazine was prepared by reaction with thionyl chloride, which was further prepared by reaction with 3, 5-dimethylbenzoyl chloride. |
| toxicity | acute oral LD50>5000mg/kg in rats,> 5000mg/kg in mice,> 2000mg/kg in mice,> 2000mg/kg in rabbits, and> 4.68mg/L (4h) in mice. It has no irritation to rabbit skin, slight irritation to rabbit eyes, and no sensitization. Through the test of rats and mice, no carcinogenic effect was found, no effect on mouse reproduction, and the teratogenic test of rabbits and mice was negative. Rainbow trout LC50>18.9mg/L, carp> 47.25mg/L, shrimp> 189mg/L (all 96). Earthworm LD50>1000mg/kg. Japanese quail acute oral LD50>5000mg/kg. Bees touch LD50>100 μg/animal, stomach poison LD50>133 μg/animal (both 48h). Algae NOEC>1000mg/kg (72h). |
| chemical properties | pure product is white crystal, melting point 186.4 ℃, vapor pressure 4 × 10-9Pa(25 ℃), solubility in water 1.12mg/L (20 ℃). |
| production method | using m-methylphenol as the starting material, cyclohydrazine is prepared through the following series of reactions. |
Last Update：2024-04-10 22:41:30
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